Pkd1 haploinsufficiency increases renal damage and induces microcyst formation following ischemia/reperfusion

AP Bastos, K Piontek, AM Silva, D Martini… - Journal of the …, 2009 - journals.lww.com
Mutations in PKD1 cause the majority of cases of autosomal dominant polycystic kidney
disease (ADPKD). Because polycystin 1 modulates cell proliferation, cell differentiation, and
apoptosis, its lower biologic activity observed in ADPKD might influence the degree of injury
after renal ischemia/reperfusion. We induced renal ischemia/reperfusion in 10-to 12-wk-old
male noncystic Pkd1+/− and wild-type mice. Compared with wild-type mice, heterozygous
mice had higher fractional excretions of sodium and potassium and higher serum creatinine …