Metabolomics reveals a key role for fumarate in mediating the effects of NADPH oxidase 4 in diabetic kidney disease
YH You, T Quach, R Saito, J Pham… - Journal of the American …, 2016 - journals.lww.com
The NADPH oxidase (NOX) isoform NOX4 has been linked with diabetic kidney disease
(DKD). However, a mechanistic understanding of the downstream effects of NOX4 remains
to be established. We report that podocyte-specific induction of NOX4 in vivo was sufficient
to recapitulate the characteristic glomerular changes noted with DKD, including glomerular
hypertrophy, mesangial matrix accumulation, glomerular basement membrane thickening,
albuminuria, and podocyte dropout. Intervention with a NOX1/NOX4 inhibitor reduced …
(DKD). However, a mechanistic understanding of the downstream effects of NOX4 remains
to be established. We report that podocyte-specific induction of NOX4 in vivo was sufficient
to recapitulate the characteristic glomerular changes noted with DKD, including glomerular
hypertrophy, mesangial matrix accumulation, glomerular basement membrane thickening,
albuminuria, and podocyte dropout. Intervention with a NOX1/NOX4 inhibitor reduced …