Exploitation of the host ubiquitin system by human bacterial pathogens

H Ashida, M Kim, C Sasakawa - Nature Reviews Microbiology, 2014 - nature.com
H Ashida, M Kim, C Sasakawa
Nature Reviews Microbiology, 2014nature.com
Ubiquitylation is a crucial post-translational protein modification that regulates several
cellular processes in eukaryotes, including inflammatory responses, endocytic trafficking
and the cell cycle. Importantly, ubiquitylation also has a central role in modulating eukaryotic
defence systems; however, accumulating evidence shows that many bacterial pathogens
exploit host ubiquitin systems for their own benefit. In this Review, we highlight the ways in
which human bacterial pathogens target ubiquitylation to subvert and manipulate host …
Abstract
Ubiquitylation is a crucial post-translational protein modification that regulates several cellular processes in eukaryotes, including inflammatory responses, endocytic trafficking and the cell cycle. Importantly, ubiquitylation also has a central role in modulating eukaryotic defence systems; however, accumulating evidence shows that many bacterial pathogens exploit host ubiquitin systems for their own benefit. In this Review, we highlight the ways in which human bacterial pathogens target ubiquitylation to subvert and manipulate host defence systems, with a focus on the role of molecular mimicry and secreted bacterial effector proteins. These strategies enable bacterial pathogens to maximize effector function and obtain nutrients, thereby promoting bacterial proliferation.
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