Peroxisome proliferator–activated receptor γ (PPARγ) is a nuclear receptor, originally
described in adipose tissue, which controls the expression of a large number of regulatory
genes in lipid metabolism and insulin sensitization. Well known by endocrinologists,
thiazolidinedionesare classical PPARγ synthetic agonists, which were currently used as
insulin-sensitizing agents in the treatment of type 2 diabetes. Although the clinical benefits of
thiazolidinediones in treating metabolic disorders have been clearly demonstrated, studies …