[HTML][HTML] Metagenomic biomarker discovery and explanation

N Segata, J Izard, L Waldron, D Gevers, L Miropolsky… - Genome biology, 2011 - Springer
Genome biology, 2011Springer
This study describes and validates a new method for metagenomic biomarker discovery by
way of class comparison, tests of biological consistency and effect size estimation. This
addresses the challenge of finding organisms, genes, or pathways that consistently explain
the differences between two or more microbial communities, which is a central problem to
the study of metagenomics. We extensively validate our method on several microbiomes
and a convenient online interface for the method is provided at http://huttenhower. sph …
Abstract
This study describes and validates a new method for metagenomic biomarker discovery by way of class comparison, tests of biological consistency and effect size estimation. This addresses the challenge of finding organisms, genes, or pathways that consistently explain the differences between two or more microbial communities, which is a central problem to the study of metagenomics. We extensively validate our method on several microbiomes and a convenient online interface for the method is provided at http://huttenhower.sph.harvard.edu/lefse/ .
Springer