[HTML][HTML] Th1/Th2 balance and Th17/Treg-mediated immunity in relation to murine resistance to dextran sulfate-induced colitis

F Yang, D Wang, Y Li, L Sang, J Zhu, J Wang… - Journal of immunology …, 2017 - hindawi.com
F Yang, D Wang, Y Li, L Sang, J Zhu, J Wang, B Wei, C Lu, X Sun
Journal of immunology research, 2017hindawi.com
Background. The role of the Th17/Treg balance in the development of experimental colitis
remains poorly understood. Methods. We exploited the differential response of BALB/c mice
and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS)
challenge. Results. DSS-resistant BALB/c mice were characterized by low levels of IFN-γ
and TNF-α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and
mesenteric lymph node (MLN) CD4+ CD25+ FoxP3+ T cells when compared to C57BL/6 …
Background
The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood.
Methods
We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge.
Results
DSS-resistant BALB/c mice were characterized by low levels of IFN-γ and TNF-α but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4+CD25+FoxP3+ T cells when compared to C57BL/6 mice. Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis.
Conclusions
The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis.
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