[HTML][HTML] Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells
M Rouse, NP Singh, PS Nagarkatti… - British journal of …, 2013 - ncbi.nlm.nih.gov
British journal of pharmacology, 2013•ncbi.nlm.nih.gov
Background and Purpose Dietary indole derivatives, indole-3-carbinol (I3C) and
diindolylmethane (DIM), possess anti-cancer properties and exhibit the characteristics of aryl
hydrocarbon receptor (AhR) ligands. Because AhR activation has recently been shown to
regulate T cell differentiation, we tested the hypothesis that I3C and DIM may mediate anti-
inflammatory properties by promoting regulatory T cell (T-regs) differentiation while inhibiting
Th17 cells.
diindolylmethane (DIM), possess anti-cancer properties and exhibit the characteristics of aryl
hydrocarbon receptor (AhR) ligands. Because AhR activation has recently been shown to
regulate T cell differentiation, we tested the hypothesis that I3C and DIM may mediate anti-
inflammatory properties by promoting regulatory T cell (T-regs) differentiation while inhibiting
Th17 cells.
Abstract
Background and Purpose
Dietary indole derivatives, indole-3-carbinol (I3C) and diindolylmethane (DIM), possess anti-cancer properties and exhibit the characteristics of aryl hydrocarbon receptor (AhR) ligands. Because AhR activation has recently been shown to regulate T cell differentiation, we tested the hypothesis that I3C and DIM may mediate anti-inflammatory properties by promoting regulatory T cell (T-regs) differentiation while inhibiting Th17 cells.
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