NASH leading cause of liver transplant in women: updated analysis of indications for liver transplant and ethnic and gender variances
M Noureddin, A Vipani, C Bresee, T Todo… - Official journal of the …, 2018 - journals.lww.com
M Noureddin, A Vipani, C Bresee, T Todo, IK Kim, N Alkhouri, VW Setiawan, T Tran…
Official journal of the American College of Gastroenterology| ACG, 2018•journals.lww.comOBJECTIVES: Chronic infection with hepatitis C virus (HCV) was previously the leading
indication for liver transplant (LT) in the United States. However, since 2014 the use of direct-
acting antivirals (DAAs) has decreased the chronic HCV burden, while the prevalence of
nonalcoholic steatohepatitis (NASH) has risen substantially through the last decade. Both
gender and ethnic disparities in indications for LT have been shown in the past but no data
on this have been reported since the implementation of DAAs. METHODS: We assessed …
indication for liver transplant (LT) in the United States. However, since 2014 the use of direct-
acting antivirals (DAAs) has decreased the chronic HCV burden, while the prevalence of
nonalcoholic steatohepatitis (NASH) has risen substantially through the last decade. Both
gender and ethnic disparities in indications for LT have been shown in the past but no data
on this have been reported since the implementation of DAAs. METHODS: We assessed …
Abstract
OBJECTIVES:
Chronic infection with hepatitis C virus (HCV) was previously the leading indication for liver transplant (LT) in the United States. However, since 2014 the use of direct-acting antivirals (DAAs) has decreased the chronic HCV burden, while the prevalence of nonalcoholic steatohepatitis (NASH) has risen substantially through the last decade. Both gender and ethnic disparities in indications for LT have been shown in the past but no data on this have been reported since the implementation of DAAs.
METHODS:
We assessed changes in etiologies for LT listing and in gender and ethnic differences in those listed for LT. Adult patients registered for LT in the United Network for Organ Sharing/Organ Procurement and Transplantation Network database between January 1, 2004 and December 31, 2016 were included. Multinomial logistic regression modeling was used to test for changes in waitlist or liver transplant rates.
RESULTS:
Lippincott Williams & Wilkins