Apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway-dependent cytoplasmic translocation of the orphan nuclear receptor NR4A2 is required for oxidative stress …
p38 mitogen-activated protein kinases (MAPKs) play important roles in various cellular
stress responses, including cell death, which is roughly categorized into apoptosis and
necrosis. Although p38 signaling has been extensively studied, the molecular mechanisms
of p38-mediated cell death are unclear. ASK1 is a stress-responsive MAP3K that acts as an
upstream kinase of p38 and is activated by various stresses, such as oxidative stress. Here,
we show that NR4A2, a member of the NR4A nuclear receptor family, acts as a necrosis …
stress responses, including cell death, which is roughly categorized into apoptosis and
necrosis. Although p38 signaling has been extensively studied, the molecular mechanisms
of p38-mediated cell death are unclear. ASK1 is a stress-responsive MAP3K that acts as an
upstream kinase of p38 and is activated by various stresses, such as oxidative stress. Here,
we show that NR4A2, a member of the NR4A nuclear receptor family, acts as a necrosis …
