Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling
S Shiizaki, I Naguro, H Ichijo - Advances in biological regulation, 2013 - Elsevier
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein
kinase kinase kinase family. ASK1 activates c-jun N-terminal kinase (JNK) and p38 in
response to various stimuli such as oxidative stress, endoplasmic reticulum stress, infection
and calcium influx. Under these stress conditions, ASK1 plays important roles in intracellular
signaling pathways and biological functions. Diverse proteins are known to interact with
ASK1 and regulate the activity of ASK1. However, activation mechanisms of ASK1 and ASK1 …
kinase kinase kinase family. ASK1 activates c-jun N-terminal kinase (JNK) and p38 in
response to various stimuli such as oxidative stress, endoplasmic reticulum stress, infection
and calcium influx. Under these stress conditions, ASK1 plays important roles in intracellular
signaling pathways and biological functions. Diverse proteins are known to interact with
ASK1 and regulate the activity of ASK1. However, activation mechanisms of ASK1 and ASK1 …
