The rat Digit Abduction Score (DAS) assay: a physiological model for assessing botulinum neurotoxin-induced skeletal muscle paralysis
RS Broide, J Rubino, GS Nicholson, MC Ardila… - Toxicon, 2013 - Elsevier
Botulinum neurotoxins (BoNT) are approved for a number of therapeutic indications,
including blepharospasm, cervical dystonia and hyperhidrosis, and have also shown
efficacy in a variety of pain disorders. The potency of any given BoNT preparation can be
routinely assessed by using the Digit Abduction Score (DAS) assay, which measures the
local muscle weakening efficacy of BoNT following injection into mouse hindlimb muscle.
While most studies have employed mice to assess BoNT efficacy in the DAS, few have …
including blepharospasm, cervical dystonia and hyperhidrosis, and have also shown
efficacy in a variety of pain disorders. The potency of any given BoNT preparation can be
routinely assessed by using the Digit Abduction Score (DAS) assay, which measures the
local muscle weakening efficacy of BoNT following injection into mouse hindlimb muscle.
While most studies have employed mice to assess BoNT efficacy in the DAS, few have …