Effect of 4-aminopyridine on the development of experimental botulism
VV Morrison, GN Kryzhanovskiĭ - Biulleten'Eksperimental'noi …, 1985 - europepmc.org
VV Morrison, GN Kryzhanovskiĭ
Biulleten'Eksperimental'noi Biologii i Meditsiny, 1985•europepmc.orgThe studies of survival and the life span of mice and the toxin in LD50 have shown that 4-
aminopyridine (4-AP) at doses of 1, 2 and 5 mg/kg has a therapeutic effect on type C
botulinic intoxication. Maximum protective effect is observed when 4-AP at a dose of 2 mg/kg
is injected twice daily. Therefore, 4-AP, enhancing the transmitter release into cholinergic
synapses, weakens the toxic effect of botulinic toxin.
aminopyridine (4-AP) at doses of 1, 2 and 5 mg/kg has a therapeutic effect on type C
botulinic intoxication. Maximum protective effect is observed when 4-AP at a dose of 2 mg/kg
is injected twice daily. Therefore, 4-AP, enhancing the transmitter release into cholinergic
synapses, weakens the toxic effect of botulinic toxin.
The studies of survival and the life span of mice and the toxin in LD50 have shown that 4-aminopyridine (4-AP) at doses of 1, 2 and 5 mg/kg has a therapeutic effect on type C botulinic intoxication. Maximum protective effect is observed when 4-AP at a dose of 2 mg/kg is injected twice daily. Therefore, 4-AP, enhancing the transmitter release into cholinergic synapses, weakens the toxic effect of botulinic toxin.
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