[HTML][HTML] Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation

SM Pope, PC Fulkerson, C Blanchard, HS Akei… - Journal of Biological …, 2005 - ASBMB
Pulmonary eosinophilia, a hallmark pathologic feature of allergic lung disease, is regulated
by interleukin-13 (IL-13) as well as the eotaxin chemokines, but the specific role of these
cytokines and their cooperative interaction are only partially understood. First, we elucidated
the essential role of IL-13 in the induction of the eotaxins by comparing IL-13 gene-targeted
mice with wild type control mice by using an ovalbumin-induced model of allergic airway
inflammation. Notably, ovalbumin-induced expressions of eotaxin-1 and eotaxin-2 mRNA in …