L-arginine is a precursor for nitrate biosynthesis in humans
CD Leaf, JS Wishnok, SR Tannenbaum - Biochemical and biophysical …, 1989 - Elsevier
CD Leaf, JS Wishnok, SR Tannenbaum
Biochemical and biophysical research communications, 1989•ElsevierNitrogen from L-arginine was incorporated into urinary nitrate in human subjects. Two
subjects given an oral dose of [15 N 2] L-arginine excreted 24 and 17 umol [15 N]
nitrate/24hr, respectively, in their urine in the 24 hr period following the dose. This work
demonstrates that L-arginine, a nitrogen source for biosynthesized nitrate in cultured cells
and research animals, is a precursor for endogenously synthesized nitrate in humans.
subjects given an oral dose of [15 N 2] L-arginine excreted 24 and 17 umol [15 N]
nitrate/24hr, respectively, in their urine in the 24 hr period following the dose. This work
demonstrates that L-arginine, a nitrogen source for biosynthesized nitrate in cultured cells
and research animals, is a precursor for endogenously synthesized nitrate in humans.
Summary
Nitrogen from L-arginine was incorporated into urinary nitrate in human subjects. Two subjects given an oral dose of [15N2]L-arginine excreted 24 and 17 umol [15N]nitrate/24hr, respectively, in their urine in the 24 hr period following the dose. This work demonstrates that L-arginine, a nitrogen source for biosynthesized nitrate in cultured cells and research animals, is a precursor for endogenously synthesized nitrate in humans.
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