Characterization of inducible nitric oxide synthase expression in human airway epithelium.
FH Guo, SC Erzurum - Environmental health perspectives, 1998 - ehp.niehs.nih.gov
Nitric oxide is an important mediator of inflammatory responses in the lung and a key
regulator of pulmonary vascular and bronchomotor tone. We have shown that the inducible
nitric oxide synthase (iNOS) isoform is continuously expressed in human airway epithelium
at mRNA and protein/activity levels in vivo. However, removal of epithelial cells from the in
vivo airway environment resulted in rapid loss of iNOS expression, which suggested that
expression is dependent upon conditions and/or factors present in the airway. To investigate …
regulator of pulmonary vascular and bronchomotor tone. We have shown that the inducible
nitric oxide synthase (iNOS) isoform is continuously expressed in human airway epithelium
at mRNA and protein/activity levels in vivo. However, removal of epithelial cells from the in
vivo airway environment resulted in rapid loss of iNOS expression, which suggested that
expression is dependent upon conditions and/or factors present in the airway. To investigate …