Roles of arginase variants, atopy, and ozone in childhood asthma

MT Salam, T Islam, WJ Gauderman… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Arginases (encoded by ARG1 and ARG2 genes) might play an important
role in asthma pathogenesis through effects on nitrosative stress. Arginase expression is
upregulated in asthma and varies with TH2 cytokine levels and oxidative stress.
OBJECTIVE: We aimed to examine whether variants in these genes are associated with
asthma and whether atopy and exposures to smoking and air pollution influence the
associations. METHODS: Among non-Hispanic and Hispanic white participants of the …