[HTML][HTML] Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells
PC Hsu, YF Liao, CL Lin, WH Lin, GY Liu, HC Hung - Molecules and cells, 2014 - Elsevier
Peptidylarginine deiminase type 2 (PADI2) deiminates (or citrullinates) arginine residues in
protein to citrulline residues in a Ca 2+-dependent manner, and is found in lymphocytes and
macrophages. Vimentin is an intermediate filament protein and a well-known substrate of
PADI2. Citrullinated vimentin is found in ionomycin-induced macrophage apoptosis.
Citrullinated vimentin is the target of anti-Sa antibodies, which are specific to rheumatoid
arthritis, and play a critical role in the pathogenesis of the disease. To investigate the role of …
protein to citrulline residues in a Ca 2+-dependent manner, and is found in lymphocytes and
macrophages. Vimentin is an intermediate filament protein and a well-known substrate of
PADI2. Citrullinated vimentin is found in ionomycin-induced macrophage apoptosis.
Citrullinated vimentin is the target of anti-Sa antibodies, which are specific to rheumatoid
arthritis, and play a critical role in the pathogenesis of the disease. To investigate the role of …
