[HTML][HTML] The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation

RJ Hill, S Zozulya, YL Lu, K Ward, M Gishizky… - Experimental …, 2002 - Elsevier
OBJECTIVE: Following activation of T cells, phosphorylation of tyrosine residues occurs
through a complex signaling process involving protein tyrosine kinases, phosphatases, and
a variety of adapter molecules including Grb2. We have attempted to identify new signaling
molecules that are important for the activation response. METHODS: Using a protein
interaction screening protocol based on phage display, T-cell signaling components that
associate with the adapter molecule, Grb2, the lymphoid-specific tyrosine phosphatase Lyp …