One of the great advances in the therapy of renal disease occurred in the 1930s and was the synthesis of Drugs are the most important causes of NDI [3]. This orally administered diuretic compounds. In 1937 condition is characterized by unresponsiveness of the suphanilamides had been introduced as antimicrobio-kidney to the action of vasopressin. Thus, the adminislogical agents. In patients treated with suphanilamides, tration of desmopressin (dDAVP, a vasopressin anametabolic acidosis with alkaline urine was observed. logue acting on the V