Antidiuretic effect of hydrochlorothiazide in lithium-induced nephrogenic diabetes insipidus is associated with upregulation of aquaporin-2, Na-Cl co-transporter, and …
GH Kim, JW Lee, YK Oh, HR Chang… - Journal of the …, 2004 - journals.lww.com
Thiazides have been used in patients with nephrogenic diabetes insipidus (NDI) to
decrease urine volume, but the mechanism by which it produces the paradoxic antidiuretic
effect remains unclear. Previous studies have reported that downregulation of aquaporin-2
(AQP2) is important for the development of lithium-induced (Li-induced) polyuria and that
hydrochlorothiazide (HCTZ) increases renal papillary osmolality and Na+ concentration in
Brattleboro rats. For elucidating the molecular basis of the antidiuretic action of HCTZ in …
decrease urine volume, but the mechanism by which it produces the paradoxic antidiuretic
effect remains unclear. Previous studies have reported that downregulation of aquaporin-2
(AQP2) is important for the development of lithium-induced (Li-induced) polyuria and that
hydrochlorothiazide (HCTZ) increases renal papillary osmolality and Na+ concentration in
Brattleboro rats. For elucidating the molecular basis of the antidiuretic action of HCTZ in …