Integrative biology identifies shared transcriptional networks in CKD

S Martini, V Nair, BJ Keller, F Eichinger… - Journal of the …, 2014 - journals.lww.com
A previous meta-analysis of genome-wide association data by the Cohorts for Heart and
Aging Research in Genomic Epidemiology and CKDGen consortia identified 16 loci
associated with eGFR. To define how each of these single-nucleotide polymorphisms
(SNPs) could affect renal function, we integrated GFR-associated loci with regulatory
pathways, producing a molecular map of CKD. In kidney biopsy specimens from 157
European subjects representing nine different CKDs, renal transcript levels for 18 genes in …