Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
Context Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
in US children and adolescents and can present with advanced fibrosis or nonalcoholic
steatohepatitis (NASH). No treatment has been established. Objective To determine whether
children with NAFLD would improve from therapeutic intervention with vitamin E or
metformin. Design, Setting, and Patients Randomized, double-blind, double-dummy,
placebo-controlled clinical trial conducted at 10 university clinical research centers in 173 …
in US children and adolescents and can present with advanced fibrosis or nonalcoholic
steatohepatitis (NASH). No treatment has been established. Objective To determine whether
children with NAFLD would improve from therapeutic intervention with vitamin E or
metformin. Design, Setting, and Patients Randomized, double-blind, double-dummy,
placebo-controlled clinical trial conducted at 10 university clinical research centers in 173 …