Cigarette Smoking Increases Human Vitamin E Requirements as Estimated by Plasma Deuterium‐Labeled CEHC
SW Leonard, RS Bruno… - Annals of the New …, 2004 - Wiley Online Library
Annals of the New York Academy of Sciences, 2004•Wiley Online Library
Cigarette smoking (CS) is a well‐described oxidant burden in humans. We hypothesized
that CS would accelerate α‐tocopherol (α‐T) utilization leaving less for metabolite (CEHC)
production. After labeled α‐T consumption (75 mg each of d3‐RRR‐α‐TAc and d6‐all‐rac‐α‐
TAc) by smokers and nonsmokers (n= 10/group), CS increased α‐T disappearance and
decreased plasma and urinary CEHCs. Plasma d3/d6‐α‐T ratios were approximately 1.4
during supplementation and approximately 2 from days 5 to 17. d3/d6‐α‐CEHC ratios were …
that CS would accelerate α‐tocopherol (α‐T) utilization leaving less for metabolite (CEHC)
production. After labeled α‐T consumption (75 mg each of d3‐RRR‐α‐TAc and d6‐all‐rac‐α‐
TAc) by smokers and nonsmokers (n= 10/group), CS increased α‐T disappearance and
decreased plasma and urinary CEHCs. Plasma d3/d6‐α‐T ratios were approximately 1.4
during supplementation and approximately 2 from days 5 to 17. d3/d6‐α‐CEHC ratios were …
Abstract: Cigarette smoking (CS) is a well‐described oxidant burden in humans. We hypothesized that CS would accelerate α‐tocopherol (α‐T) utilization leaving less for metabolite (CEHC) production. After labeled α‐T consumption (75 mg each of d3‐RRR‐α‐TAc and d6‐all‐rac‐α‐TAc) by smokers and nonsmokers (n= 10/group), CS increased α‐T disappearance and decreased plasma and urinary CEHCs. Plasma d3/d6‐α‐T ratios were approximately 1.4 during supplementation and approximately 2 from days 5 to 17. d3/d6‐α‐CEHC ratios were on average 0.29 ± 0.05, confirming that all‐rac‐α‐tocopherol is metabolized more efficiently. CEHC may be a good marker of vitamin E status, and smokers may have an increased vitamin E requirement.
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