Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double‐blinded, randomized, controlled study
A Lassnigg, A Punz, R Barker, P Keznickl… - British Journal of …, 2003 - academic.oup.com
A Lassnigg, A Punz, R Barker, P Keznickl, N Manhart, E Roth, M Hiesmayr
British Journal of Anaesthesia, 2003•academic.oup.comBackground. IV infusions of vitamin E emulsion (all‐rac‐α‐tocopherol) may reduce
ischaemia–reperfusion injury after elective cardiac surgery. Methods. Forty patients
participated in a prospective, double‐blind, placebo‐controlled, randomized trial, receiving
either placebo or four doses (270 mg each) of all‐rac‐α‐tocopherol between 16 h before
and 48 h after surgery. We determined plasma concentrations of vitamin E, vitamin C,
malondialdehyde, creatine kinase, troponin I and interleukin 6 and other measures of …
ischaemia–reperfusion injury after elective cardiac surgery. Methods. Forty patients
participated in a prospective, double‐blind, placebo‐controlled, randomized trial, receiving
either placebo or four doses (270 mg each) of all‐rac‐α‐tocopherol between 16 h before
and 48 h after surgery. We determined plasma concentrations of vitamin E, vitamin C,
malondialdehyde, creatine kinase, troponin I and interleukin 6 and other measures of …
Abstract
Background. I.V. infusions of vitamin E emulsion (all‐rac‐α‐tocopherol) may reduce ischaemia–reperfusion injury after elective cardiac surgery.
Methods. Forty patients participated in a prospective, double‐blind, placebo‐controlled, randomized trial, receiving either placebo or four doses (270 mg each) of all‐rac‐α‐tocopherol between 16 h before and 48 h after surgery. We determined plasma concentrations of vitamin E, vitamin C, malondialdehyde, creatine kinase, troponin I and interleukin 6 and other measures of clinical outcome.
Results. Infusion of vitamin E caused normalization of vitamin E plasma concentrations during and after surgery, but had no effect on the early increase in malondialdehyde concentration or the decreases in antioxidative capacity and the water‐soluble antioxidant vitamin C.
Conclusions. Normalization of plasma vitamin E concentrations with parenteral vitamin E emulsion does not affect biochemical markers of myocardial injury and does not affect clinical outcome after cardiac surgery.
Br J Anaesth 2003; 90: 148–54
Oxford University Press