α-Tocopherol (vitamin E) is an essential nutrient for all vertebrates. From the eight naturally
occurring members of the vitamin E family, α-tocopherol is the most biologically active
species and is selectively retained in tissues. The hepatic α-tocopherol transfer protein (TTP)
preferentially selects dietary α-tocopherol and facilitates its transport through the hepatocyte
and its secretion to the circulation. In doing so, TTP regulates body-wide levels of α-
tocopherol. The mechanisms by which TTP facilitates α-tocopherol trafficking in hepatocytes …