Stimulation of lymphocyte natural cytotoxicity by L-arginine
KGM Park, PD Hayes, O Eremin, H Sewell, PJ Garlick - The lancet, 1991 - Elsevier
KGM Park, PD Hayes, O Eremin, H Sewell, PJ Garlick
The lancet, 1991•ElsevierIn vitro L-arginine enhanced natural-killer (NK) and lymphokine-activated-killer (LAK) cell
activity; this cytotoxicity was mediated by CD56+ cells. In vivo arginine supplements (30
g/day for 3 days) increased the number of circulating CD56+ cells by a median of 32% in
eight volunteers (p< 0ˇ 01); this increase was associated with a mean rise of 91% in NK cell
activity (p= 0ˇ 003) and of 58% in LAK cell activity (p= 0ˇ 001) in thirteen volunteers. These
findings have potentially important implications for the modulation of natural cytotoxicity in a …
activity; this cytotoxicity was mediated by CD56+ cells. In vivo arginine supplements (30
g/day for 3 days) increased the number of circulating CD56+ cells by a median of 32% in
eight volunteers (p< 0ˇ 01); this increase was associated with a mean rise of 91% in NK cell
activity (p= 0ˇ 003) and of 58% in LAK cell activity (p= 0ˇ 001) in thirteen volunteers. These
findings have potentially important implications for the modulation of natural cytotoxicity in a …
Abstract
In vitro L-arginine enhanced natural-killer (NK) and lymphokine-activated-killer (LAK) cell activity; this cytotoxicity was mediated by CD56+ cells. In vivo arginine supplements (30 g/day for 3 days) increased the number of circulating CD56+ cells by a median of 32% in eight volunteers (p<0ˇ01); this increase was associated with a mean rise of 91% in NK cell activity (p=0ˇ003) and of 58% in LAK cell activity (p=0ˇ001) in thirteen volunteers. These findings have potentially important implications for the modulation of natural cytotoxicity in a wide range of disease states.
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