Afferent innervation, muscle spindles, and contractures following neonatal brachial plexus injury in a mouse model
S Nikolaou, L Hu, R Cornwall - The Journal of hand surgery, 2015 - Elsevier
Purpose We used an established mouse model of elbow flexion contracture after neonatal
brachial plexus injury (NBPI) to test the hypothesis that preservation of afferent innervation
protects against contractures and is associated with preservation of muscle spindles and
ErbB signaling. Methods A model of preganglionic C5 through C7 NBPI was first tested in
mice with fluorescent axons using confocal imaging to confirm preserved afferent
innervation of spindles despite motor end plate denervation. Preganglionic and …
brachial plexus injury (NBPI) to test the hypothesis that preservation of afferent innervation
protects against contractures and is associated with preservation of muscle spindles and
ErbB signaling. Methods A model of preganglionic C5 through C7 NBPI was first tested in
mice with fluorescent axons using confocal imaging to confirm preserved afferent
innervation of spindles despite motor end plate denervation. Preganglionic and …