[HTML][HTML] The cellular regulators PTEN and BMI1 help mediate NEUROGENIN-3–induced cell cycle arrest
RS Solorzano-Vargas, M Bjerknes, SV Wu… - Journal of Biological …, 2019 - ASBMB
Neurogenin-3 (NEUROG3) is a helix-loop-helix (HLH) transcription factor involved in the
production of endocrine cells in the intestine and pancreas of humans and mice. However,
the human NEUROG3 loss-of-function phenotype differs subtly from that in mice, but the
reason for this difference remains poorly understood. Because NEUROG3 expression
precedes exit of the cell cycle and the expression of endocrine cell markers during
differentiation, we investigated the effect of lentivirus-mediated overexpression of the human …
production of endocrine cells in the intestine and pancreas of humans and mice. However,
the human NEUROG3 loss-of-function phenotype differs subtly from that in mice, but the
reason for this difference remains poorly understood. Because NEUROG3 expression
precedes exit of the cell cycle and the expression of endocrine cell markers during
differentiation, we investigated the effect of lentivirus-mediated overexpression of the human …