[HTML][HTML] Differential roles of upstream stimulatory factors 1 and 2 in the transcriptional response of liver genes to glucose
VS Vallet, M Casado, AA Henrion, D Bucchini… - Journal of Biological …, 1998 - ASBMB
USF1 and USF2 are ubiquitous transcription factors of the basic helix-loop-helix leucine
zipper family. They form homo-and heterodimers and recognize a CACGTG motif termed E
box. In the liver, USF binding activity is mainly accounted for by the USF1/USF2 heterodimer,
which binds in vitro the glucose/carbohydrate response elements (GlRE/ChoRE) of glucose-
responsive genes. To assign a physiological role of USFsin vivo, we have undertaken the
disruption of USF1 and USF2 genes in mice. We present here the generation of USF1 …
zipper family. They form homo-and heterodimers and recognize a CACGTG motif termed E
box. In the liver, USF binding activity is mainly accounted for by the USF1/USF2 heterodimer,
which binds in vitro the glucose/carbohydrate response elements (GlRE/ChoRE) of glucose-
responsive genes. To assign a physiological role of USFsin vivo, we have undertaken the
disruption of USF1 and USF2 genes in mice. We present here the generation of USF1 …