Islet changes in hereditary ceruloplasmin deficiency
T Kato, M Daimon, T Kawanami, Y Ikezawa, H Sasaki… - Human pathology, 1997 - Elsevier
Diabetes mellitus (DM) is the important initial symptom of hereditary ceruloplasmin
deficiency (HCD). We examined the pancreas of an autopsy case of HCD and revealed a
marked reduction in insulin-containing cells in the islets despite no massive iron deposition,
degeneration, nor necrosis. Non-insulin-containing cells in the islets had glucagon or
somatostatin. This study indicates that DM in HCD results from depletion of insulin cells and
this depletion does not seem to be caused by the direct effect of iron deposition. The present …
deficiency (HCD). We examined the pancreas of an autopsy case of HCD and revealed a
marked reduction in insulin-containing cells in the islets despite no massive iron deposition,
degeneration, nor necrosis. Non-insulin-containing cells in the islets had glucagon or
somatostatin. This study indicates that DM in HCD results from depletion of insulin cells and
this depletion does not seem to be caused by the direct effect of iron deposition. The present …