[HTML][HTML] Hepcidin decreases iron transporter expression in vivo in mouse duodenum and spleen and in vitro in THP-1 macrophages and intestinal Caco-2 cells
B Chung, T Chaston, J Marks, SK Srai, PA Sharp - The Journal of nutrition, 2009 - Elsevier
Hepcidin is thought to control iron metabolism by interacting with the iron efflux transporter
ferroportin. In macrophages, there is compelling evidence that hepcidin directly regulates
ferroportin protein expression. However, the effects of hepcidin on intestinal ferroportin
levels are less conclusive. In this study, we compared the effects of hepcidin on iron
transporter expression in the spleen and duodenum of mice treated with hepcidin over a 24-
to 72-h period and observed a marked decrease in the expression of ferroportin in both …
ferroportin. In macrophages, there is compelling evidence that hepcidin directly regulates
ferroportin protein expression. However, the effects of hepcidin on intestinal ferroportin
levels are less conclusive. In this study, we compared the effects of hepcidin on iron
transporter expression in the spleen and duodenum of mice treated with hepcidin over a 24-
to 72-h period and observed a marked decrease in the expression of ferroportin in both …