Iron-induced skeletal muscle atrophy involves an Akt-forkhead box O3–E3 ubiquitin ligase-dependent pathway
Y Ikeda, M Imao, A Satoh, H Watanabe… - Journal of Trace …, 2016 - Elsevier
Skeletal muscle wasting or sarcopenia is a critical health problem. Skeletal muscle atrophy
is induced by an excess of iron, which is an essential trace metal for all living organisms.
Excessive amounts of iron catalyze the formation of highly toxic hydroxyl radicals via the
Fenton reaction. However, the molecular mechanism of iron-induced skeletal muscle
atrophy has remained unclear. In this study, 8-weeks-old C57BL6/J mice were divided into 2
groups: vehicle-treated group and the iron-injected group (10 mg iron day− 1 mouse− 1) …
is induced by an excess of iron, which is an essential trace metal for all living organisms.
Excessive amounts of iron catalyze the formation of highly toxic hydroxyl radicals via the
Fenton reaction. However, the molecular mechanism of iron-induced skeletal muscle
atrophy has remained unclear. In this study, 8-weeks-old C57BL6/J mice were divided into 2
groups: vehicle-treated group and the iron-injected group (10 mg iron day− 1 mouse− 1) …