[HTML][HTML] Carboxyl terminus of apolipoprotein AI (ApoA-I) is necessary for the transport of lipid-free ApoA-I but not prelipidated ApoA-I particles through aortic …
PM Ohnsorg, L Rohrer, D Perisa, A Kateifides… - Journal of biological …, 2011 - ASBMB
High density lipoproteins (HDL) and apolipoprotein AI (apoA-I) must leave the circulation
and pass the endothelium to exert their atheroprotective actions in the arterial wall. We
previously demonstrated that the transendothelial transport of apoA-I involves ATP-binding
cassette transporter (ABC) A1 and re-secretion of lipidated particles. Transendothelial
transport of HDL is modulated by ABCG1 and the scavenger receptor BI (SR-BI). We
hypothesize that apoA-I transport is started by the ABCA1-mediated generation of a lipidated …
and pass the endothelium to exert their atheroprotective actions in the arterial wall. We
previously demonstrated that the transendothelial transport of apoA-I involves ATP-binding
cassette transporter (ABC) A1 and re-secretion of lipidated particles. Transendothelial
transport of HDL is modulated by ABCG1 and the scavenger receptor BI (SR-BI). We
hypothesize that apoA-I transport is started by the ABCA1-mediated generation of a lipidated …