Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis
Apolipoprotein F (ApoF) is a sialoglycoprotein that is a component of the HDL and LDL
fractions of human serum. We sought to test the hypothesis that ApoF plays an important role
in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed
in male low density lipoprotein receptor knockout (Ldlr KO) and ApoF/Ldlr double knockout
(DKO) mice fed a Western diet for 16 weeks. ApoF/Ldlr DKO mice showed a 39% reduction
in lesional area by en face analysis of aortas (p< 0.05), despite no significant differences in …
fractions of human serum. We sought to test the hypothesis that ApoF plays an important role
in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed
in male low density lipoprotein receptor knockout (Ldlr KO) and ApoF/Ldlr double knockout
(DKO) mice fed a Western diet for 16 weeks. ApoF/Ldlr DKO mice showed a 39% reduction
in lesional area by en face analysis of aortas (p< 0.05), despite no significant differences in …
