Plasma C20-Sphingolipids predict cardiovascular events independently from conventional cardiovascular risk factors in patients undergoing coronary angiography
A Othman, CH Saely, A Muendlein, A Vonbank… - Atherosclerosis, 2015 - Elsevier
Aims Sphingolipids are emerging as novel players in the pathogenesis of atherosclerosis
and cardiovascular disease. Serine palmitoyltransferase (SPT) catalyzes the first and rate-
limiting step in the de novo synthesis of sphingolipids—the condensation of palmitoyl-CoA
and l-Serine. In addition to these canonical substrates, SPT can also metabolize other acyl-
CoAs and amino acids, thus generating a variety of atypical sphingoid bases. In this study,
we investigated the association of these atypical sphingoid bases with the presence of …
and cardiovascular disease. Serine palmitoyltransferase (SPT) catalyzes the first and rate-
limiting step in the de novo synthesis of sphingolipids—the condensation of palmitoyl-CoA
and l-Serine. In addition to these canonical substrates, SPT can also metabolize other acyl-
CoAs and amino acids, thus generating a variety of atypical sphingoid bases. In this study,
we investigated the association of these atypical sphingoid bases with the presence of …