Quantification of HDL proteins, cardiac events, and mortality in patients with type 2 diabetes on hemodialysis
C Kopecky, B Genser, C Drechsler… - Clinical Journal of the …, 2015 - journals.lww.com
C Kopecky, B Genser, C Drechsler, V Krane, CC Kaltenecker, M Hengstschläger, W März…
Clinical Journal of the American Society of Nephrology, 2015•journals.lww.comResults High concentrations of SAA (HDL) were significantly and positively associated with
the risk of cardiac events (hazard ratio per 1 SD higher, 1.09; 95% confidence interval, 1.01
to 1.19). High concentrations of SP-B (HDL) were significantly associated with all-cause
mortality (hazard ratio per 1 SD higher, 1.10; 95% confidence interval, 1.02 to 1.19).
Adjustment for HDL cholesterol did not affect these associations. Conclusions In patients
with diabetes on hemodialysis, SAA (HDL) and SP-B (HDL) were related to cardiac events …
the risk of cardiac events (hazard ratio per 1 SD higher, 1.09; 95% confidence interval, 1.01
to 1.19). High concentrations of SP-B (HDL) were significantly associated with all-cause
mortality (hazard ratio per 1 SD higher, 1.10; 95% confidence interval, 1.02 to 1.19).
Adjustment for HDL cholesterol did not affect these associations. Conclusions In patients
with diabetes on hemodialysis, SAA (HDL) and SP-B (HDL) were related to cardiac events …
Results
High concentrations of SAA (HDL) were significantly and positively associated with the risk of cardiac events (hazard ratio per 1 SD higher, 1.09; 95% confidence interval, 1.01 to 1.19). High concentrations of SP-B (HDL) were significantly associated with all-cause mortality (hazard ratio per 1 SD higher, 1.10; 95% confidence interval, 1.02 to 1.19). Adjustment for HDL cholesterol did not affect these associations.
Conclusions
In patients with diabetes on hemodialysis, SAA (HDL) and SP-B (HDL) were related to cardiac events and all-cause mortality, respectively, and they were independent of HDL cholesterol. These findings indicate that a remodeling of the HDL proteome was associated with a higher risk for cardiovascular events and mortality in patients with ESRD.
Lippincott Williams & Wilkins