Major changes in the sphingophospholipidome of HDL in non-diabetic patients with metabolic syndrome
D Denimal, A Nguyen, JPP de Barros, B Bouillet… - Atherosclerosis, 2016 - Elsevier
Objective Phospholipids and sphingolipids play a critical role in the protective effects of HDL
against atherosclerosis. These properties are impaired in patients with metabolic syndrome,
before the development of diabetes. We thus investigated whether HDL from patients with
metabolic syndrome but normal fasting glycaemia present abnormalities in their
sphingophospholipid profile. Methods Using liquid chromatography/tandem mass
spectrometry, we quantified the different species of the main phospholipids and …
against atherosclerosis. These properties are impaired in patients with metabolic syndrome,
before the development of diabetes. We thus investigated whether HDL from patients with
metabolic syndrome but normal fasting glycaemia present abnormalities in their
sphingophospholipid profile. Methods Using liquid chromatography/tandem mass
spectrometry, we quantified the different species of the main phospholipids and …
