Limited cleavage of human immunoglobulins by elastase of human neutrophil polymorphonuclear granulocytes. Possible modulator of immune complex disease.
JD Folds, H Prince, JK Spitznagel - Laboratory investigation; a …, 1978 - europepmc.org
JD Folds, H Prince, JK Spitznagel
Laboratory investigation; a journal of technical methods and pathology, 1978•europepmc.orgHuman polymorphonuclear lysosomal granules contain a neutral protease which is capable
of digesting human immunoglobulins. The protease is located in the azurophil granules and
enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like
fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by
native antibody from which the fragments were produced.
of digesting human immunoglobulins. The protease is located in the azurophil granules and
enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like
fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by
native antibody from which the fragments were produced.
Human polymorphonuclear lysosomal granules contain a neutral protease which is capable of digesting human immunoglobulins. The protease is located in the azurophil granules and enzymatically cleaves IgG, producing a Fab-like piece which is recoverable. The Fc-like fragment is not crystallized. The Fab-like fragment competes effectively for ligands formed by native antibody from which the fragments were produced.
europepmc.org