Cif (PA2934), a bacterial virulence factor secreted in outer membrane vesicles by
Pseudomonas aeruginosa, increases the ubiquitination and lysosomal degradation of some,
but not all, plasma membrane ATP-binding cassette transporters (ABC), including the cystic
fibrosis transmembrane conductance regulator and P-glycoprotein. The goal of this study
was to determine whether Cif enhances the ubiquitination and degradation of the transporter
associated with antigen processing (TAP1 and TAP2), members of the ABC transporter …