[HTML][HTML] The ins and outs of cholesterol in the vertebrate retina

SJ Fliesler, L Bretillon - Journal of Lipid Research, 2010 - ASBMB
The vertebrate retina has multiple demands for utilization of cholesterol and must meet those
demands either by synthesizing its own supply of cholesterol or by importing cholesterol
from extraretinal sources, or both. Unlike the blood-brain barrier, the blood-retina barrier
allows uptake of cholesterol from the circulation via a lipoprotein-based/receptor-mediated
mechanism. Under normal conditions, cholesterol homeostasis is tightly regulated; also,
cholesterol exists in the neural retina overwhelmingly in unesterified form, and sterol …