The mouse is one of the most commonly used mammalian systems to study human
diseases. In particular it has been an invaluable tool to model a multitude of ocular
pathologies affecting the posterior pole. The aim of this study was to create a comprehensive
map of the ultrastructure of the mouse posterior pole using the quick-freeze/deep-etch
method (QFDE). QFDE can produce detailed three-dimensional images of tissue structure
and macromolecular moieties, without many of the artifacts introduced by structure-altering …