Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by nitric oxide production in an intracranial rat glioma+ vaccination model
W Jia, C Jackson-Cook, MR Graf - Journal of neuroimmunology, 2010 - Elsevier
In rats bearing an intracranial T9 glioma, immunization with tumor antigens induces myeloid
suppressor cells, which express neutrophil (His48) and monocyte (CD11bc) markers, to
infiltrate the tumors. The His48+/CD11bc+ cells were not derived from CNS microglia but
were hematogenous; suppressed multiple T cell effector functions; and are myeloid-derived
suppressor cells (MDSC). The glioma-infiltrating MDSC expressed arginase I, iNOS,
indoleamine 2, 3-dioxygenase and TGF-β; however, inhibitor/blocking studies demonstrated …
suppressor cells, which express neutrophil (His48) and monocyte (CD11bc) markers, to
infiltrate the tumors. The His48+/CD11bc+ cells were not derived from CNS microglia but
were hematogenous; suppressed multiple T cell effector functions; and are myeloid-derived
suppressor cells (MDSC). The glioma-infiltrating MDSC expressed arginase I, iNOS,
indoleamine 2, 3-dioxygenase and TGF-β; however, inhibitor/blocking studies demonstrated …