[HTML][HTML] Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport
Myosin Va is a member of the unconventional class V myosin family, and a mutation in the
myosin Va gene causes pigment granule transport defects in human Griscelli syndrome and
dilute mice. How myosin Va recognizes its cargo (ie melanosomes), however, has re-
mained undetermined over the past decade. In this study, we discovered Slac2-
a/melanophilin to be the" missing link" between myosin Va and GTP-Rab27A present in the
melanosome. Deletion analysis and site-directed mutagenesis showed that the N-terminal …
myosin Va gene causes pigment granule transport defects in human Griscelli syndrome and
dilute mice. How myosin Va recognizes its cargo (ie melanosomes), however, has re-
mained undetermined over the past decade. In this study, we discovered Slac2-
a/melanophilin to be the" missing link" between myosin Va and GTP-Rab27A present in the
melanosome. Deletion analysis and site-directed mutagenesis showed that the N-terminal …