Lipolytic action of glucagon-like peptides in isolated rat adipocytes
C Ruiz-Grande, C Alarcón, E Mérida, I Valverde - Peptides, 1992 - Elsevier
The lipolytic effect of GLP-1 (1–36)-amide, GLP-1 (7–36) amide and GLP-2 [proglucagon
(126–159)] has been studied in isolated rat adipocytes. Glycerol release and cyclic AMP
content were measured after incubation of adipocytes with GLPs and results have been
compared with those obtained in the presence of glucagon. GLP-1 (7–36)-amide and GLP-1
(1–36)-amide at 10− 8, 10− 7 and 10− 6 M concentrations activated glycerol release, the
truncated peptide having a more potent effect. On the other hand, GLP-2 had no effect on …
(126–159)] has been studied in isolated rat adipocytes. Glycerol release and cyclic AMP
content were measured after incubation of adipocytes with GLPs and results have been
compared with those obtained in the presence of glucagon. GLP-1 (7–36)-amide and GLP-1
(1–36)-amide at 10− 8, 10− 7 and 10− 6 M concentrations activated glycerol release, the
truncated peptide having a more potent effect. On the other hand, GLP-2 had no effect on …
