Beta-cell selective KATP-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity
RA Ritzel, S Jayasinghe, JB Hansen, J Sturis… - Regulatory peptides, 2010 - Elsevier
BACKGROUND AND AIMS: In type 2 diabetes mellitus (T2DM) chronic beta-cell stimulation
and oligomers of aggregating human islet amyloid polypeptide (h-IAPP) cause beta-cell
dysfunction and induce beta-cell apoptosis. Therefore we asked whether beta-cell rest
prevents h-IAPP induced beta-cell apoptosis. MATERIALS AND METHODS: We induced
beta-cell rest with a beta-cell selective KATP-channel opener (KATPCO) in RIN cells and
human islets exposed to h-IAPP versus r-IAPP. Apoptosis was quantified by time-lapse …
and oligomers of aggregating human islet amyloid polypeptide (h-IAPP) cause beta-cell
dysfunction and induce beta-cell apoptosis. Therefore we asked whether beta-cell rest
prevents h-IAPP induced beta-cell apoptosis. MATERIALS AND METHODS: We induced
beta-cell rest with a beta-cell selective KATP-channel opener (KATPCO) in RIN cells and
human islets exposed to h-IAPP versus r-IAPP. Apoptosis was quantified by time-lapse …