[HTML][HTML] Pancreatic islet amyloidosis, β-cell apoptosis, and α-cell proliferation are determinants of islet remodeling in type-2 diabetic baboons
R Guardado-Mendoza, AM Davalli… - Proceedings of the …, 2009 - National Acad Sciences
β-Cell dysfunction is an important factor in the development of hyperglycemia of type-2
diabetes mellitus, and pancreatic islet amyloidosis (IA) has been postulated to be one of the
main contributors to impaired insulin secretion. The aim of this study was to evaluate the
correlation of IA with metabolic parameters and its effect on islets of Langerhans remodeling
and relative endocrine-cell volume in baboons. We sequenced the amylin peptide,
determined the fibrillogenic propensities, and evaluated pancreatic histology, clinical and …
diabetes mellitus, and pancreatic islet amyloidosis (IA) has been postulated to be one of the
main contributors to impaired insulin secretion. The aim of this study was to evaluate the
correlation of IA with metabolic parameters and its effect on islets of Langerhans remodeling
and relative endocrine-cell volume in baboons. We sequenced the amylin peptide,
determined the fibrillogenic propensities, and evaluated pancreatic histology, clinical and …