[HTML][HTML] Mitotic arrest with nocodazole induces selective changes in the level of O-linked N-acetylglucosamine and accumulation of incompletely processed N-glycans …
RS Haltiwanger, GA Philipsberg - Journal of Biological Chemistry, 1997 - ASBMB
O-LinkedN-acetylglucosamine (O-GlcNAc) is a ubiquitous and abundant protein
modification found on nuclear and cytoplasmic proteins. Several lines of evidence suggest
that it is a highly dynamic modification and that the levels of this sugar on proteins may be
regulated. Previous workers (Chou, CF, and Omary, MB (1993) J. Biol. Chem. 268, 4465-
4472) have shown that mitotic arrest with microtubule-destabilizing agents such as
nocodazole causes an increase in the O-GlcNAc levels on keratins in the human colon …
modification found on nuclear and cytoplasmic proteins. Several lines of evidence suggest
that it is a highly dynamic modification and that the levels of this sugar on proteins may be
regulated. Previous workers (Chou, CF, and Omary, MB (1993) J. Biol. Chem. 268, 4465-
4472) have shown that mitotic arrest with microtubule-destabilizing agents such as
nocodazole causes an increase in the O-GlcNAc levels on keratins in the human colon …