[HTML][HTML] Perturbations in O-linked β-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis
C Slawson, NE Zachara, K Vosseller… - Journal of Biological …, 2005 - ASBMB
The dynamic modification of nuclear and cytoplasmic proteins with O-linked β-N-
acetylglucosamine (O-GlcNAc) is a regulatory post-translational modification that is rapidly
responsive to morphogens, hormones, nutrients, and cellular stress. Here we show that O-
GlcNAc is an important regulator of the cell cycle. Increased O-GlcNAc (pharmacologically or
genetically) results in growth defects linked to delays in G 2/M progression, altered mitotic
phosphorylation, and cyclin expression. Overexpression of O-GlcNAcase, the enzyme that …
acetylglucosamine (O-GlcNAc) is a regulatory post-translational modification that is rapidly
responsive to morphogens, hormones, nutrients, and cellular stress. Here we show that O-
GlcNAc is an important regulator of the cell cycle. Increased O-GlcNAc (pharmacologically or
genetically) results in growth defects linked to delays in G 2/M progression, altered mitotic
phosphorylation, and cyclin expression. Overexpression of O-GlcNAcase, the enzyme that …