[HTML][HTML] The emerging link between O-GlcNAc and Alzheimer disease
Regional glucose hypometabolism is a defining feature of Alzheimer disease (AD). One
emerging link between glucose hypometabolism and progression of AD is the nutrient-
responsive post-translational O-GlcNAcylation of nucleocytoplasmic proteins. O-GlcNAc is
abundant in neurons and occurs on both tau and amyloid precursor protein. Increased brain
O-GlcNAcylation protects against tau and amyloid-β peptide toxicity. Decreased O-
GlcNAcylation occurs in AD, suggesting that glucose hypometabolism may impair the …
emerging link between glucose hypometabolism and progression of AD is the nutrient-
responsive post-translational O-GlcNAcylation of nucleocytoplasmic proteins. O-GlcNAc is
abundant in neurons and occurs on both tau and amyloid precursor protein. Increased brain
O-GlcNAcylation protects against tau and amyloid-β peptide toxicity. Decreased O-
GlcNAcylation occurs in AD, suggesting that glucose hypometabolism may impair the …