[HTML][HTML] Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis
C Keembiyehetty, DC Love, KR Harwood… - Journal of Biological …, 2015 - ASBMB
O-GlcNAc cycling is maintained by the reciprocal activities of the O-GlcNAc transferase and
the O-GlcNAcase (OGA) enzymes. O-GlcNAc transferase is responsible for O-GlcNAc
addition to serine and threonine (Ser/Thr) residues and OGA for its removal. Although the
Oga gene (MGEA5) is a documented human diabetes susceptibility locus, its role in
maintaining insulin-glucose homeostasis is unclear. Here, we report a conditional disruption
of the Oga gene in the mouse. The resulting homozygous Oga null (KO) animals lack OGA …
the O-GlcNAcase (OGA) enzymes. O-GlcNAc transferase is responsible for O-GlcNAc
addition to serine and threonine (Ser/Thr) residues and OGA for its removal. Although the
Oga gene (MGEA5) is a documented human diabetes susceptibility locus, its role in
maintaining insulin-glucose homeostasis is unclear. Here, we report a conditional disruption
of the Oga gene in the mouse. The resulting homozygous Oga null (KO) animals lack OGA …